In a large-scale cohort study, British researchers examined the medical data of over 16,000 patients. You identified, what risk factors are for a serious Covid-19-the course responsible. In it they confirm previous assumptions about the age and pre-existing conditions.

The Coronavirus dominated the whole world. Researchers are working to learn as much as possible about the pathogen and the disease it triggers. The best way in which you look at the disease processes in Covid-19 patients.

So approximately 166 hospitals in the United Kingdom were also involved in a large study with 16.749 patients suffering from Covid-19. Scientists at the University of Liverpool had access to data from February to mid-April 2020.

With their results, the researchers were able to support previous scientific assumptions. Previously, it was assumed that severe cases of Covid-19 hung, especially with increased age (over 50 years) and pre-existing conditions together. The researchers published their findings on the prePrint Server “medRxiv”. The study is, therefore, not yet been tested by independent researchers.

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Age and pre-existing conditions

On average, the patients were 72 years of age, of whom approximately 60 percent are men. Among the approximately 40% men, 55 for women, 6 percent were pregnant. The patients showed that four days prior to admission to the hospital the first symptoms, in the hospital, they stopped for an average of seven days. University of Liverpool Among the patients were about 60 percent men and 40 percent women. On average, the patients were 72 years of age.

In addition to the age pre-existing conditions played a role. As the most common diseases, the scientists determined:

• Chronic Heart Disease (29 Percent)
• Diabetes (19 Percent)
• non-asthmatic chronic lung diseases (19 percent)
• Asthma (14 Percent)

Other chronic diseases, Obesity , and dementia were among the risky pre-existing conditions. However, the investigations of scientists revealed that around half of patients, 47 percent, had no pre-existing conditions.

Coughing or sick to my stomach? Researchers identify clusters

The researchers were able to draw also conclusions regarding the frequency of symptoms. Especially were widely used in the process:

• Cough (70%)
• Fever (69 percent) and
• Shortness Of Breath (65%)

Only 4 percent of the patients showed no symptoms at all. According to the scientists, the most common symptoms often appeared together. They found three clusters:

Respiratory: Cough, Sputum, Shortness Of Breath, Fever

Systemic: Muscle Pain, Joint Pain, Fatigue

Enteric: abdominal pain, vomiting, and diarrhea University of Liverpool , The British scientists identified three symptom clusters. The respiratory included cough, sputum, shortness of breath and fever.

A total of 29 percent of the patients complained about enteric symptoms, i.e. those relating to the bowel, and only 4 percent were suffering, however, alone among these.  

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About 50 percent of the mechanically Ventilated died

Over the observation period, approximately 49 percent of the Patients were discharged from the hospital, about 33 per cent died.

About 17 percent were cared for. Of those who were treated on an intensive care unit, died, 45 percent. Of all patients who were mechanically ventilated died even 53 percent.

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