The material cause of Obesity and Diabetes discovered
Too much sugar and fat is unhealthy, thick and with a number of diseases is connected, it should actually be aware of. But the question of why this is so, one inevitably comes across the question mark. What are the mechanisms in the body that we grow when we feed bad? The answer lies in the metabolism. A German research team has deciphered the cause of Obesity and Diabetes, and was able to choke by a small operation of these processes in the Bud.
Eat what you want without being sick and gaining weight – sounds like a utopia. However, considering the metabolic processes for weight gain responsible, it shows that everything is just a matter of biochemistry. This research showed the end of the Max-Planck-Institute for metabolism research. You decrypted the metabolic process in the body that we start out fat. At the same time this is also the basis of a type 2 Diabetes. Through a small intervention in the metabolism, the Team was able to show in obese mice, and that these decreases in spite of an unhealthy and fat-rich diet suddenly and no Diabetes developed. The results of the study were recently published in the renowned scientific journal “Cell”.
Is high-fat diet with a healthy life style compatible?
Fatty liver, Diabetes, metabolic syndrome, heart disease, bowel cancer: The list of serious diseases associated with an unhealthy diet, is a long one. In contrast, only a consistent and long-term change in Diet, the discipline, and the background helps to the time knowledge requires. Many people, however, have to deal don’t have the time or desire to go with the topic of nutrition, so intense. You want to eat what you want. A sugar – and fat-rich diet with a healthy lifestyle, agree? Maybe Yes, says the research team at the Max-Planck-society.
What happens in the body when we fat eat too much
The researchers studied in mice, which processes in metabolism cause the body fat. From previous studies it is already gone forth, that the adipose tissue cannot store excess fat only to a certain degree. This point is exceeded, it will store more fat molecules in muscles and the liver. These inclusions lay the Foundation for the development of fatty liver and insulin resistance that lead to type 2 Diabetes.
Not all fats are equally involved in the formation of fat
A certain group of fat-molecules is largely responsible for this process. The so-called ceramides are Compounds that bind to fatty acids. They are produced by metabolic processes, if we are to take fat-rich food to us. This process is called ceramide Synthase. In previous studies it was already trying to prevent this Synthase. However, this led to significant side effects. The Max-Planck-research group was able to provide a breakdown of the ceramide Synthase in detail.
Why do fat fat?
“In a complete inhibition of ceramide synthesis is disturbed, for example, the development of the animals”, explains Dr. Philipp Hammerschmidt from the research group in a press release of the study results. The Team looked at therefore, which of the different ceramide synthases are exactly involved in the pathogenesis of insulin resistance. The Team identified a specific subset of ceramides, the anlagerten in the liver of obese mice. According to the study, these ceramide-have-molecules of a certain length and are formed by the ceramide synthases 5 and 6. In further Tests, the researchers expressed only in the formation of this sub-group specifically. “Interestingly, but could only protect the inactivation of ceramide Synthase 6 in mice from obesity, fatty liver, and insulin resistance. The loss of the ceramide Synthase 5, however, had no effect,“ says Hammerschmidt.
Ceramide-retention inhibit the energy budget
The researchers reports that affect the ceramides from the Synthase 6 the structure and function of mitochondria, so the cells responsible for the production of energy in the body. In the case of an excessively fat and sugar – rich diet, ceramide Synthase 6, stored in the mitochondria and inhibited in the long term, their function. In this process, the researchers see the cause for Obesity and related diseases.
Obese mice that ate itself with a high-fat diet slim
When the research team blocked specifically the ceramide 6 Synthase in mice, something amazing happened: “The mice ate still a lot of fat, but lost weight while improving your sugar metabolism,” says Hammerschmidt. Such a regulation is for humans to imagine. This needs to be investigated in further studies more precisely. (vb)