Female mice destined to develop Alzheimer’s-like pathology and related cognitive impairments display a unique pattern of fluctuation in sex hormones during the ovarian cycle, finds new research published in eNeuro. This study suggests the natural reproductive cycle may provide a new window into Alzheimer’s Disease (AD) risk among young women.

AD begins to develop decades before the first clinical symptoms emerge. This means the disease may already be progressing during a woman’s reproductive years. Dena Dubal and colleagues asked whether the hormones—specifically estrogen—released during the natural ovarian cycle promote disease progression in at-risk individuals.

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