It would be a huge – and, above all, fiercely contested jump in research: A Chinese scientists, babies are the world to come, for the first time after a genetic manipulation to the world. It should be twin girls from China who were treated in the embryonic stage of the Genschere Crispr/Cas9. The intervention may have made the children’s resistant to HIV.
“Two beautiful little Chinese girl named Lulu and Nana came a few weeks ago crying and as healthy as any other Baby to the world,” said the head of research He Jiankui from the University in Shenzhen. So far, the statements of the researcher are not only known to be a reviewed scientific publication procedures.
However, He Jiankui has entered the trial in a Chinese Register for clinical trials. According to him, he has changed the embryo of six other pairs during artificial fertilization of genetically. The men were He found to be HIV-positive and the women HIV-negative. The idea of his research is, therefore, to make the embryos of these couples against a HIV-infection-resistant.
Nowadays, it is to prevent, optimally adjusted drug therapy are often possible for the partners to infect each other or the Virus to her child transferred.
Cure diseases, or more beautiful?
“If the news is true that now, but the first two babies were born after a targeted germ-line modification by Crispr, it would be a clear sign of an irresponsible rush ahead of individual scientists,” said Jochen Taupitz, managing Director of the Institute for German, European and International medical law.
Also the U.S. researcher Jennifer Doudna, one of the Developers of Crispr/Cas9, criticized on Monday in Hong Kong: “If this is confirmed, this work is a break with the restrained and transparent approach of the global scientific community in the application of Crispr/Cas9 Editing of the human germline.” It was urgently needed to put the genetic engineering of Embryos with clear boundaries. They should only be used where a clear medical necessity exists and no other method of treatment existed.
The specific genetic changes of the embryo is that these are later found in the germ cells such as Egg or sperm cell and thus to the next Generation to be inherited.
With the Genschere Crispr, researchers can genotype as accurate and cheap to change, like never before. You can change the function of genes, is turned off or a Gene through a different exchange. The technique is used in the research in many cases, such as in microorganisms and plants. For the wide application in the people you apply the most researchers so far, however, is still uncertain.
Thus, Crispr works-Cas9
Proponents of the technology are raving at the idea that one could repair using Crispr-Cas9 genetic defects in the Embryo and, hence, serious genetic diseases such as cystic fibrosis, sickle cell anemia, or muscular dystrophy prevent. Critics fear, however, that the technology could be used to create people with more muscles or musical Talent.
In the past year, researchers from the USA reported that it had managed to liberate embryos using the Crispr/Cas9 hereditary diseases. However, the researchers allowed the embryos only up to an early stage of growth, in which they consisted of a few dozen cells. Babies were not born.
“Irresponsible People Will Try To”
The ethical issues that accompany the new technology, are complex. Because a genetic manipulation of the Embryo not only affects individuals, at least when he or she plants.
How strongly should people be allowed to intervene not only in the genome of an Individual, but in the following generations? What forms of hereditary diseases and disabilities are so bad that they should be fixed before birth? And if it prevents diseases, you can inject not Desired?
Due to the serious consequences of the attitude in Germany is to the method and its application in people.
“In the experiments, it is irresponsible human trials,” said Peter Dabrock, Chairman of the German ethics Council, to Hes delivery. “Whether it is true or not, what the Chinese researchers He claims: at The present time such Attempts, and also announcements are criticizing in the strongest possible terms.” According to the almost unanimous assessment of the basic research is still far away from use in humans. “The consequences of low and late, unpredictable and hard to control.”
Internationally Hes alleged Attempts were criticised massively: “This is yet immature a lot,” said Eric Topol, Director of Scripps Research Translational Institute of California in relation to the method. “We operate here with the instructions for use for a human.” Kiran Musunuru, Genexperte of the University of Pennsylvania, said: “This is unconscionable. An Experiment on people, which is neither morally nor ethically acceptable.”
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